Idiotypy and autoimmunity
نویسندگان
چکیده
منابع مشابه
Perspectives on antigenicity and idiotypy.
The recent crystal determination of a lysozyme-antilysozyme complex provides a three-dimensional prototype of the manner in which contacts in idiotype-anti-idiotype interactions may be realized. Such interactions can be approximated by two complementary "flat" surfaces. Each IDR (autoantigenic locus) location might provide a particular recognition feature between two interacting partners. The c...
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Sera of rabbits immunized against Salmonella typhi have been studied for the idiotypy of certain of their components, i.e., the property of these components to possess an antigenic specificity which is different in individual rabbits, and which varies with the antigens against which these rabbits have been immunized. The reagent used (precipitating anti-idiotypic sera) have been prepared by inj...
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Cell surface receptors function as specific binding structures for a wide variety of ligands, including antigens, hormones, toxins, and viruses. For recognition of antigen by B lymphocytes, the basis of receptor binding to ligand relates to the arrangement of variable regions of heavy and light immunoglobulin (Ig) chains, creating novel conformational structures in and around the binding site t...
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Gene association studies are less appealing in cancer compared to autoimmune diseases. Complexity, heterogeneity, variation in histological types, age at onset, short survival, and acute versus chronic conditions are cancer related factors which are different from an organ specific autoimmune disease, such as Grave’s disease, on which a large body of multicentre data is accumulated. For years t...
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Background: The relationship between thyroid autoimmunity and breast cancer is a challenging subject. We aimed to investigate this association in women with breast cancer. Methods: In this descriptive study, 41 women with newly diagnosed breast cancer before receiving any pharmacologic treatment and 38 healthy age-matched women were enrolled. Anti TPO Ab (anti-thyroid peroxidase antibodies), FT...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 1986
ISSN: 0004-3591,1529-0131
DOI: 10.1002/art.1780290601